It’s a classic catch-22. As the population has swollen around the world, we’ve had to produce increasingly more food to support ourselves, relying on plant domestication to feed our growing numbers. As a result, crops have lost their natural defense mechanisms, leading to agrochemical abuse and pest resistance. While plant domestication has improved characteristics like yield and growth, it has sacrificed certain natural defense mechanisms. Crops are no longer as resilient as they once were, resulting in a global crisis making farmers lose billions and threatening the world’s food supply.
Officially launched in 2023 (on the heels of seventeen years of academic research), Semion has developed a novel pest control technology that activates crop defense mechanisms that have been weeded out through industrial domestication. They achieve this using phytostimulants—compounds that manipulate plants’ defense pathways. Modern industrial agriculture methods rely on agrochemicals that create pest resistance, ineffective repellents, or genetically modified seeds and plants. Instead, Semion manipulates the metabolic pathways of crops to activate the natural plant defense mechanisms lost during domestication.

Lucia Ferrari and Victoria Coll at Semion doing lab work.
Semion’s first two developments focus on controlling two major threats to global agriculture: Dalbulus maidis, the vector of corn stunt disease, and Diaphorina citri, the vector of citrus greening disease. Semion has focused on these pests as they are prime examples of massive crop destruction. Diaphorina citri has devastated 80% of Florida’s citrus industry since 2005, while Dalbulus maidis is destroying corn crops across South America, causing over $2 billion in losses in Argentina last year alone, and rapidly spreading toward the US. For corn stunt disease, Semion protects the crops by making the plant more resistant to both the insect’s damage and the effects of the disease it transmits. In field trials they obtained, among other promising results, a 30% average yield increase compared to infected controls. To combat citrus greening disease, Semion has developed a push-pull approach that makes citrus plants emit specific odors to repel the insect while simultaneously attracting it to traps for elimination. After 12 months of field trials with the University of Florida, they say they’re achieving 100% disease control.

From left to right: Gabriela Valladares, Jorge Hill, Emilce Viruel, Facundo Herrera, Victoria Coll, Alejandro Forlin, Paula Paez
Semion’s ingenious technology has many positive benefits for our food planet. The initiative’s solution can lead to increased food security for vulnerable communities. By protecting farmers’ crops, they achieve higher yields and better-quality produce, which translates into increased earnings. This boost in income not only supports individual farmers but also stimulates the local economy. Reducing the need for agrochemicals drastically lowers the exposure of farm workers to dangerous substances, thereby improving their health and safety. This reduction in chemical use also prevents water contamination—which in turn, keeps communities healthier and safer.
Its technology has the potential to be applied to any crop in any geography, with six solutions already in the pipeline. Its first product for controlling Dalbulus maidis is ready and set for commercial launch this year, and the company is in discussions with major agrochemical companies about manufacturing and distribution across four countries. By focusing on the commercialization of the Dalbulbus maidis control product, Semion aims to address the immediate needs of farmers facing this challenge, demonstrating the effectiveness of its technology and laying a solid foundation for future expansion.
Read more about Semion.
Written by Sarah Souli
Photos provided by the initiative